New fertility research reveals comparable embryo transfer outcomes for transgender men and cisgender women
Transgender men achieve similar IVF live birth rates and embryo outcomes as cisgender women, providing evidence for equitable fertility guidance.
SAN ANTONIO, TX [October 28, 2025] – A new study from US Fertility highlights that transgender men undergoing in vitro fertilization (IVF) experience live birth and embryo development outcomes comparable to cisgender women who had a transgender male partner. The findings that were presented at the 81st ASRM Scientific Congress & Expo, provide critical data to support fertility care for transgender patients.
While prior research on fertility care for transgender men has largely focused on egg retrieval outcomes, this study is among the first and largest to examine both embryo development and transfer outcomes in this population.
“Our findings demonstrate that transgender men can achieve pregnancy outcomes on par with cisgender women, even in patients with prior testosterone exposure,” shares Kyle N. Le, M.D., lead author and Reproductive Endocrinology and Infertility Fellow at Shady Grove Fertility in Virginia. “This data provides important reassurance to patients and informs clinical counseling and decision-making.”
The study analyzed 24 transgender men who underwent 27 IVF cycles and 50 cisgender women who underwent 61 IVF cycles as a comparison group. Key findings include:
Cumulative live birth was 83% for embryos from transgender males and 69% for embryos from cisgender females
Live birth per embryo transfer was 63% for embryos from transgender males versus 41% for cisgender females.
Embryo development outcomes were comparable between groups.
Among transgender males with prior testosterone exposure, live birth outcomes were similar to those without prior exposure.
“US Fertility is committed to advancing inclusive reproductive medicine,” says Phillip Romanski, M.D., M.Sc., senior author and Associate Research Director for US Fertility. “This study helps ensure access to evidence-based guidance and supports inclusive care across all patient populations.”
These findings mark the largest cohort to report embryo transfer outcomes for transgender men to date, providing both patients and providers with valuable data to guide fertility planning and treatment decisions.
Learn more about US Fertility’s Research Division, which conducts and publishes high-quality studies to advance the field of reproductive medicine and provide better, more effective care to infertility patients.
ABOUT US FERTILITY
US Fertility, the nation’s largest partnership of physician-owned and physician-led top-tier fertility practices and IVF laboratories, are united under a shared mission to deliver the joy of parenthood through advanced reproductive medicine and innovative science. To date, US Fertility practices and laboratories have helped more than 225,000 individuals and couples build their families using assisted reproductive technology. US Fertility supports over 200 physicians by leveraging collective expertise, driving innovation, and by providing advanced business and digital solutions that streamline and enhance the delivery of exceptional patient care. Together with a growing suite of life science services, US Fertility is expanding access to the highest quality reproductive health care across over 105 clinic locations and 35 IVF laboratories. https://www.usfertility.com